"There were a lot of guys coming through and there was a lot of pressure on the line," said Wiggan, who rushed 21 times for 115 yards and a score. "They were blitzing a lot of guys, but we were expecting that. This is just frustrating."
The fumble was the sixth lost (seventh overall) for the Vaqueros.
The attempted hand-off came with 1:03 remaining in the fourth quarter on a third and goal.
Moments earlier, it appeared Glendale scored when sophomore running back Timothy Broughton (21 carries for 99 yards) punched in a four-yard touchdown with 1:52 remaining, only to have the score nullified on a holding call.
"We have a good team, but we just continue to struggle in key moments," Glendale Coach John Rome said. "We struggled with untimely penalties, we struggled with fumbles and third-down stops."
The Vaqueros surrendered two touchdowns in the second half – one on a Josh Johnson five-yard touchdown carry and the other a 33-yard touchdown from quarterback Jake Basmajian to receiver Martin Hill for 33 yards.
The Hill reception came with 9:06 left in the fourth quarter and put the Brahmas up, 28-14.
Glendale responded with a three-play, 34-yard drive capped by a four-yard touchdown by Omar Barrera-Sanchez, which after a blocked extra point, brought the Vaqueros within 28-20 with 8:10 remaining.
Glendale needed to drive only a short distance thanks to a 55-yard kick return from Osa Aikhionbare.
The Vaqueros' only other score of the second half came with 13:26 left in the fourth on a nine-yard carry from Barrera-Sanchez.
The visiting Brahmas led, 14-7, in a wild first half.
With the score tied at seven, on second and 34, Vaqueros' quarterback Darren Orsbern (who later left the game with an undisclosed injury) fumbled a potential handoff that was recovered by Pierce's Marcus Jenkins at the Glendale 33.