In addition to closing operations at those two airports, the airline said it plans to cut 150 positions.
"Our objective is to make our company competitive and more efficient in an increasingly challenging industry," the airline said in a statement Monday.
The flights from Bob Hope Airport will end Feb. 9. The last flight from Chicago to India will leave Feb. 28.
The airline blamed the jobs cut partly to the loss of the U.S. Postal Service domestic mail contract.
-- Hugo Martin, Los Angeles Times